IQCH

Across TCGA cell cohorts, IQCH mutation is significantly associated with the RNA expression of many other genes, with 255 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IQCH-associated genes across cancer lineages are IZUMO1R, LRIT1, and TNP1. Each is linked with IQCH in more than 1 cancer types. Because this analysis shows association rather than direction, both IQCH-to-partner and partner-to-IQCH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IZUMO1R grouped by IQCH-low versus IQCH-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCH→partner) and Y-score (partner→IQCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IZUMO1R →	+0.053	+4.736	<.001	.009	3	2
BLOOD_Leukemia	LRIT1 →	+0.043	+4.269	<.001	.002	3	2
SOFT_TISSUE	TNP1 →	+1.481	+5.369	<.001	.004	3	1
SOFT_TISSUE	RLN3 →	+0.041	+5.369	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	PAX4 →	+0.022	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	MAGEB4 →	+0.026	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 255 associations by consensus.

IZUMO1R by IQCH expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →