IQCF1

Across TCGA cell cohorts, IQCF1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IQCF1-associated genes across cancer lineages are SPO11, UGT2B11, and ACER1. Each is linked with IQCF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IQCF1-to-partner and partner-to-IQCF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPO11 grouped by IQCF1-low versus IQCF1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCF1→partner) and Y-score (partner→IQCF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPO11 →	+0.019	+4.969	<.001	.003	3	1
SKIN	UGT2B11 →	+0.023	+4.930	.003	.001	3	1
LARGE_INTESTINE	ACER1 →	+0.092	+4.145	.001	.001	3	1
LARGE_INTESTINE	OR2C1 →	+0.098	+3.725	.003	.008	3	1
LARGE_INTESTINE	H1-6 →	+0.113	+3.509	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SPO11 by IQCF1 expression — BLOOD_Leukemia

Explore this box plot interactively →