IQCD

Across TCGA patient cohorts, IQCD protein abundance is significantly associated with the RNA expression of many other genes, with 1,370 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IQCD-associated genes across cancer lineages are CCL7, APH1A, and DPH3. Each is linked with IQCD in more than 1 cancer types. Because this analysis shows association rather than direction, both IQCD-to-partner and partner-to-IQCD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IQCD versus CCL7 in LSCC, with a Pearson correlation of -0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCD→partner) and Y-score (partner→IQCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CCL7 →	-0.865	-0.975	.003	.009	3	1
LSCC	APH1A →	-0.372	-1.217	.002	<.001	3	1
LSCC	DPH3 →	-0.487	-1.111	<.001	.004	3	1
LSCC	RCAN1 →	-1.007	-1.280	.001	<.001	3	1
LSCC	NKX3-1 →	+1.411	+1.104	.001	.002	3	1
LSCC	SAA1 →	+2.922	+1.027	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,370 associations by consensus.

IQCD vs CCL7 — LSCC

Explore this scatter interactively →