IQCD

Across TCGA pan-cancer cohorts, IQCD RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of IQCD’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where IQCD RNA is repressed in tumor relative to normal tissue. In most cancer types IQCD is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and LIHC are the cancer types where IQCD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IQCD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.537	<.001	11	view →
KIRC	Male	II,III,IV	−0.758	<.001	10	view →
LIHC	All	II,III,IV	+1.057	<.001	9	view →
BRCA	All	III,IV	+1.004	<.001	6	view →
LUSC	All	All	−0.816	<.001	6	view →
STAD	All	All	+0.535	<.001	4	view →
KIRP	All	II,III,IV	+0.598	.018	3	view →
CHOL	Male	All	+2.438	<.001	2	view →
ESCA	All	II,III,IV	+0.940	.037	2	view →
HNSC	All	II,III,IV	−0.395	.036	2	view →
PRAD	All	All	−0.171	.029	2	view →
BLCA	All	IV	+0.688	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

IQCD–KICH

Open the KICH breakdown →