IQCD

Across TCGA patient cohorts, IQCD mutation is significantly associated with the RNA expression of many other genes, with 1,050 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQCD-associated genes across cancer lineages are RN7SKP135, CST2P1, and RNU4ATAC7P. Each is linked with IQCD in more than 1 cancer types. Because this analysis shows association rather than direction, both IQCD-to-partner and partner-to-IQCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP135 grouped by IQCD-low versus IQCD-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCD→partner) and Y-score (partner→IQCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RN7SKP135 →	+0.267	+5.105	.001	.008	3	2
BRCA	CST2P1 →	+0.704	+9.057	<.001	.003	3	2
BRCA	RNU4ATAC7P →	+0.222	+8.055	<.001	.007	3	1
SKCM	ELOCP18 →	+0.210	+3.661	.002	.009	3	1
SKCM	RN7SL342P →	+0.095	+5.408	<.001	.002	3	1
SKCM	SLC16A1P1 →	+0.020	+4.614	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,050 associations by consensus.

RN7SKP135 by IQCD expression — STAD

Explore this box plot interactively →