IQCD

Across TCGA cell cohorts, IQCD mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IQCD-associated genes across cancer lineages are TAS2R39, OR10G4, and MAJIN. Each is linked with IQCD in more than 1 cancer types. Because this analysis shows association rather than direction, both IQCD-to-partner and partner-to-IQCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS2R39 grouped by IQCD-low versus IQCD-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCD→partner) and Y-score (partner→IQCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TAS2R39 →	+0.043	+4.906	<.001	.006	3	1
SOFT_TISSUE	OR10G4 →	+0.024	+4.930	.004	.008	3	1
LARGE_INTESTINE	MAJIN →	+0.111	+3.554	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TAS2R39 by IQCD expression — OESOPHAGUS

Explore this box plot interactively →