IQCD

Across TCGA cell cohorts, IQCD mutation is significantly associated with the mutation status of many other genes, with 954 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IQCD-associated genes across cancer lineages are OSBPL1A, TTF1, and CCDC66. Each is linked with IQCD in more than 3 cancer types. Because this analysis shows association rather than direction, both IQCD-to-partner and partner-to-IQCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OSBPL1A grouped by IQCD-low versus IQCD-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCD→partner) and Y-score (partner→IQCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OSBPL1A →	+2.652	+3.471	.004	.004	1	4
BLOOD_Lymphoma	TTF1 →	+4.014	+4.969	.008	.008	1	3
LARGE_INTESTINE	CCDC66 →	+2.652	+3.471	.004	.004	1	3
SOFT_TISSUE	IFT140 →	+5.502	+5.502	.003	.003	1	3
SOFT_TISSUE	CNTNAP3 →	+4.502	+5.066	.007	.007	1	3
LARGE_INTESTINE	ABCA2 →	+1.693	+3.506	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 954 associations by consensus.

OSBPL1A by IQCD expression — LARGE_INTESTINE

Explore this box plot interactively →