IQCB1

Across TCGA patient cohorts, IQCB1 mutation is significantly associated with the RNA expression of many other genes, with 914 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQCB1-associated genes across cancer lineages are ERHP2, RNU6-1311P, and SCARNA21B. Each is linked with IQCB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IQCB1-to-partner and partner-to-IQCB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERHP2 grouped by IQCB1-low versus IQCB1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCB1→partner) and Y-score (partner→IQCB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ERHP2 →	+0.218	+4.418	<.001	.008	3	2
UCEC	RNU6-1311P →	+0.222	+2.602	.005	.006	3	2
LUSC	SCARNA21B →	+0.285	+3.849	<.001	.006	3	2
UCEC	FARSBP1 →	+0.078	+2.230	<.001	.005	3	2
UCEC	RNU6ATAC14P →	+0.440	+2.311	<.001	.004	3	2
UCEC	LINC02707 →	+0.079	+2.707	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 914 associations by consensus.

ERHP2 by IQCB1 expression — COAD

Explore this box plot interactively →