IQCB1

Across TCGA pan-cancer cohorts, IQCB1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of IQCB1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IQCB1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IQCB1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, LIHC, and HNSC are the cancer types where IQCB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IQCB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.540	<.001	11	view →
LIHC	Female	II,III,IV	+1.142	<.001	9	view →
HNSC	Male	III,IV	+1.199	<.001	8	view →
COAD	Male	II,III,IV	+0.758	<.001	8	view →
BLCA	All	III,IV	+0.810	.001	6	view →
STAD	All	II,III,IV	+0.771	<.001	6	view →
CHOL	Female	All	+2.630	<.001	5	view →
LUSC	All	All	+0.852	<.001	5	view →
KICH	Female	All	−0.772	.004	3	view →
READ	All	All	+0.656	.001	3	view →
ESCA	All	All	+0.880	.009	1	view →
LUAD	All	All	+0.231	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

IQCB1–KIRC

Open the KIRC breakdown →