IQCB1

Across TCGA patient cohorts, IQCB1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQCB1-associated genes across cancer lineages are TFRC, C-Raf, and eEF2. Each is linked with IQCB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IQCB1-to-partner and partner-to-IQCB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by IQCB1-low versus IQCB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCB1→partner) and Y-score (partner→IQCB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.490	+2.700	.040	.006	3	2
UCEC	C-Raf →	+0.225	+2.000	<.001	.032	3	2
UCEC	eEF2 →	+0.361	+2.000	.025	.032	3	1
UCEC	EGFR_pY1068 →	-0.319	-2.321	.004	.034	3	1
UCEC	FoxM1 →	+0.260	+2.817	.025	.036	3	1
UCEC	GATA6 →	-0.195	-1.992	.005	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

TFRC by IQCB1 expression — UCEC

Explore this box plot interactively →