IQCA1L

Across TCGA cell cohorts, IQCA1L RNA expression is significantly associated with the go_rna of many other GO terms, with 874 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IQCA1L-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Regulation of protein autoubiquitination, and Negative regulation of DNA-templated transcription, elongation. Each is linked with IQCA1L in more than 6 cancer types. Because this analysis shows association rather than direction, both IQCA1L-to-partner and partner-to-IQCA1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by IQCA1L-low versus IQCA1L-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCA1L→partner) and Y-score (partner→IQCA1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of gene expression, epigenetic →	+0.060	+0.071	.001	.003	3	7
PANCREAS	Regulation of protein autoubiquitination →	+0.132	+0.033	<.001	.007	3	6
LUNG_NSCLC_LUSC	Negative regulation of DNA-templated transcription, elongation →	+0.122	+0.068	<.001	.004	3	6
OVARY	Cytoplasmic translation →	+0.067	+0.057	.002	.008	3	6
SOFT_TISSUE	DNA topological change →	+0.123	+0.020	<.001	.004	3	6
CNS	Negative regulation of transcription elongation by RNA polymerase II →	+0.057	+0.023	.005	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 874 associations by consensus.

Negative regulation of gene expression, epigenetic by IQCA1L expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →