IQCA1L

Across TCGA pan-cancer cohorts, IQCA1L RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IQCA1L’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where IQCA1L RNA is repressed in tumor relative to normal tissue. In most cancer types IQCA1L is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.

BRCA, UCEC, and THCA are the cancer types where IQCA1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IQCA1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	II,III,IV	−0.022	.001	6	view →
UCEC	All	IV	+0.080	.015	2	view →
THCA	Female	All	−0.015	.018	2	view →
KIRC	Male	All	+0.010	.005	2	view →
COAD	Male	III,IV	−0.021	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

IQCA1L–BRCA

Open the BRCA breakdown →