IPO9-AS1

Across TCGA pan-cancer cohorts, IPO9-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IPO9-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher IPO9-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IPO9-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and THYM show a favorable association.

ACC, LIHC, and KICH are the cancer types where IPO9-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.236	0.672	<.001	138	view →
LIHC	DFS	Quartile	All	0.354	0.531	.001	53	view →
KICH	DFS	Tertile	All	0.584	1.000	.002	43	view →
LGG	DFS	Median	All	0.665	0.807	<.001	42	view →
LUSC	OS	Tertile	All	0.737	0.589	<.001	42	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.575	<.001	35	view →
MESO	DFS	Quartile	All	0.214	0.492	<.001	33	view →
UCEC	DFS	Quartile	All	0.829	0.944	<.001	28	view →
READ	DFS	Median	II,III,IV	0.361	0.719	.008	23	view →
KIRC	DFS	Tertile	All	0.541	0.705	.008	22	view →
LUAD	OS	Median	II,III,IV	0.293	0.197	.025	19	view →
OV	OS	Quartile	III,IV	0.874	0.744	.020	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IPO9-AS1–ACC (DFS)

Open the ACC breakdown →