IPO9-AS1

Across TCGA pan-cancer cohorts, IPO9-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IPO9-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where IPO9-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types IPO9-AS1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where IPO9-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IPO9-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.461	<.001	10	view →
THCA	Male	All	−0.376	<.001	9	view →
LIHC	All	II,III,IV	+0.200	<.001	9	view →
HNSC	Male	III,IV	+0.291	<.001	8	view →
CHOL	Male	All	+0.583	<.001	3	view →
LUAD	All	IV	+0.394	.010	2	view →
READ	Female	All	−0.264	.022	2	view →
LUSC	All	All	+0.195	.008	2	view →
COAD	Male	III,IV	+0.143	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

IPO9-AS1–KICH

Open the KICH breakdown →