IPO8

Across TCGA patient cohorts, IPO8 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,978 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IPO8-associated proteins across cancer lineages are SRSF9, HNRNPL, and CMAS. Each is linked with IPO8 in more than 4 cancer types. Because this analysis shows association rather than direction, both IPO8-to-partner and partner-to-IPO8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IPO8 versus SRSF9 in GBM, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IPO8→partner) and Y-score (partner→IPO8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SRSF9 →	+0.365	+0.290	.005	.006	3	5
HNSC	HNRNPL →	+0.238	+0.749	<.001	.001	3	5
OV	CMAS →	+0.723	+0.430	<.001	.003	3	5
OV	CCDC91 →	+0.606	+0.516	<.001	<.001	3	5
GBM	NBEAL2 →	-0.426	-0.275	<.001	<.001	3	4
HNSC	NONO →	+0.241	+0.525	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,978 associations by consensus.

IPO8 vs SRSF9 — GBM

Explore this scatter interactively →