IPO8

Across TCGA patient cohorts, IPO8 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IPO8-associated genes across cancer lineages are GAPDH, ATM, and EGFR_pY1068. Each is linked with IPO8 in more than 3 cancer types. Because this analysis shows association rather than direction, both IPO8-to-partner and partner-to-IPO8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by IPO8-low versus IPO8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPO8→partner) and Y-score (partner→IPO8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.332	+1.064	.043	.048	3	4
UCEC	ATM →	-0.674	-2.222	<.001	<.001	3	4
UCEC	EGFR_pY1068 →	-0.296	-1.947	<.001	<.001	3	2
UCEC	eIF4E →	+0.130	+2.713	.044	.003	3	2
UCEC	MEK1 →	+0.340	+2.415	.002	.002	3	2
UCEC	p62 Lck ligand →	+0.433	+2.584	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

GAPDH by IPO8 expression — UCEC

Explore this box plot interactively →