IPO8

Across TCGA cell cohorts, IPO8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,927 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IPO8-associated GO terms across cancer lineages are Nuclear transport, Regulation of chromosome condensation, and Positive regulation of organelle assembly. Each is linked with IPO8 in more than 14 cancer types. Because this analysis shows association rather than direction, both IPO8-to-partner and partner-to-IPO8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear transport grouped by IPO8-low versus IPO8-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IPO8→partner) and Y-score (partner→IPO8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Nuclear transport →	+0.076	+1.104	<.001	<.001	3	15
STOMACH	Regulation of chromosome condensation →	+0.155	+0.987	<.001	.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of organelle assembly →	+0.086	+1.284	<.001	<.001	3	14
OVARY	Regulation of mitotic metaphase/anaphase transition →	+0.098	+0.785	<.001	.005	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of sister chromatid segregation →	+0.123	+0.889	.004	.006	3	14
BLOOD_Leukemia	Positive regulation of cell cycle →	+0.059	+0.859	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,927 associations by consensus.

Nuclear transport by IPO8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →