IPO8

Across TCGA cell cohorts, IPO8 mutation is significantly associated with the RNA expression of many other genes, with 273 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IPO8-associated genes across cancer lineages are SALL3, USP29, and TAS2R39. Each is linked with IPO8 in more than 1 cancer types. Because this analysis shows association rather than direction, both IPO8-to-partner and partner-to-IPO8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SALL3 grouped by IPO8-low versus IPO8-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPO8→partner) and Y-score (partner→IPO8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SALL3 →	+0.379	+4.115	<.001	.001	3	2
OESOPHAGUS	USP29 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	TAS2R39 →	+0.043	+4.906	<.001	.006	3	1
LARGE_INTESTINE	RPL3 →	+0.419	+3.087	.007	.006	3	1
LARGE_INTESTINE	GNPNAT1 →	+0.573	+2.129	.001	.007	3	1
LARGE_INTESTINE	DHODH →	+0.570	+3.125	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 273 associations by consensus.

SALL3 by IPO8 expression — SKIN

Explore this box plot interactively →