IPO5P1

Across TCGA pan-cancer cohorts, IPO5P1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IPO5P1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IPO5P1 RNA is repressed in tumor relative to normal tissue. In most cancer types IPO5P1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LUAD are the cancer types where IPO5P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IPO5P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.152	<.001	11	view →
KICH	Male	All	−1.716	<.001	10	view →
LUAD	Female	III,IV	−1.473	<.001	9	view →
LUSC	Male	All	−0.890	<.001	7	view →
LIHC	Male	All	+0.861	<.001	6	view →
THCA	Male	II,III,IV	−0.708	<.001	6	view →
BRCA	Female	All	−0.517	<.001	6	view →
HNSC	Female	II,III,IV	−0.669	.019	2	view →
KIRP	All	All	−0.463	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

IPO5P1–KIRC

Open the KIRC breakdown →