Across TCGA cell cohorts, IPO4 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IPO4-associated genes across cancer lineages are MBD3L3, MBD3L4, and SLC7A10. Each is linked with IPO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IPO4-to-partner and partner-to-IPO4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPO4→partner) and Y-score (partner→IPO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MBD3L3 →	+0.020	+4.906	<.001	.006	3	1
OESOPHAGUS	MBD3L4 →	+0.020	+4.906	<.001	.006	3	1
SKIN	SLC7A10 →	+0.390	+4.095	<.001	.009	3	1
SKIN	OR1L3 →	+0.022	+4.415	<.001	.007	3	1
LUNG_NSCLC_LUAD	AKAP4 →	+0.010	+3.544	.001	.009	3	1
LUNG_NSCLC_LUAD	OR2D2 →	+0.058	+3.977	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

IPO4 survival (RNA) · tumor vs normal (RNA) · all IPO4 data types