IP6K3

Across TCGA patient cohorts, IP6K3 mutation is significantly associated with the RNA expression of many other genes, with 3,984 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IP6K3-associated genes across cancer lineages are KIF23, EXOG, and TIPIN. Each is linked with IP6K3 in more than 2 cancer types. Because this analysis shows association rather than direction, both IP6K3-to-partner and partner-to-IP6K3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF23 grouped by IP6K3-low versus IP6K3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IP6K3→partner) and Y-score (partner→IP6K3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIF23 →	+0.739	+2.470	<.001	<.001	3	3
SKCM	EXOG →	+0.433	+3.604	.001	.001	3	3
UCEC	TIPIN →	+0.615	+2.960	<.001	<.001	3	3
UCEC	EYA3 →	+0.532	+3.971	<.001	<.001	3	3
UCEC	PATL1 →	+0.480	+2.575	.001	<.001	3	3
UCEC	ZWILCH →	+0.722	+2.470	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,984 associations by consensus.

KIF23 by IP6K3 expression — UCEC

Explore this box plot interactively →