IP6K3

Across TCGA pan-cancer cohorts, IP6K3 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated IP6K3 data layer compared with 5 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher IP6K3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IP6K3 expression acts as an unfavorable survival marker, although some lineages such as COAD and DLBC show a favorable association.

UVM, KIRP, and HNSC are the cancer types where IP6K3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.344	0.822	<.001	97	view →
KIRP	DFS	Quartile	All	0.603	0.820	<.001	57	view →
HNSC	OS	Median	II,III,IV	0.607	0.731	.005	47	view →
COAD	OS	Tertile	All	0.881	0.645	<.001	42	view →
OV	DFS	Median	III,IV	0.481	0.582	.011	34	view →
DLBC	DFS	Median	All	0.948	0.389	.001	29	view →
SCLC	DFS	Tertile	II,III,IV	0.382	0.679	.017	27	view →
STAD	DFS	Tertile	All	0.286	0.523	.005	22	view →
TGCT	DFS	Tertile	All	0.751	0.946	.004	18	view →
KIRC	DFS	Median	All	0.685	0.568	.012	16	view →
PRAD	DFS	Quartile	All	0.974	0.891	.002	16	view →
CHOL	DFS	Median	All	0.252	0.568	.013	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

IP6K3–UVM (OS)

Open the UVM breakdown →