IP6K3

Across TCGA patient cohorts, IP6K3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IP6K3-associated genes across cancer lineages are PDCD4, NDRG1_pT346, and EGFR_pY1068. Each is linked with IP6K3 in more than 2 cancer types. Because this analysis shows association rather than direction, both IP6K3-to-partner and partner-to-IP6K3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by IP6K3-low versus IP6K3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IP6K3→partner) and Y-score (partner→IP6K3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.582	-2.502	.001	.002	3	3
SKCM	NDRG1_pT346 →	-0.600	-2.321	.031	.033	3	2
UCEC	EGFR_pY1068 →	-0.222	-2.000	.024	.030	3	2
UCEC	ATM →	-0.415	-1.584	.019	.036	3	2
UCEC	FoxM1 →	+0.229	+1.584	.024	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.189	-2.222	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

PDCD4 by IP6K3 expression — UCEC

Explore this box plot interactively →