IP6K3

Across TCGA cell cohorts, IP6K3 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IP6K3-associated genes across cancer lineages are OR2D3, SLC15A5, and MTNR1B. Each is linked with IP6K3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IP6K3-to-partner and partner-to-IP6K3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2D3 grouped by IP6K3-low versus IP6K3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IP6K3→partner) and Y-score (partner→IP6K3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2D3 →	+0.030	+4.095	<.001	.009	3	1
LARGE_INTESTINE	SLC15A5 →	+0.017	+4.415	<.001	.007	3	1
BLOOD_Leukemia	MTNR1B →	+0.070	+4.705	.002	.003	3	1
BLOOD_Leukemia	PIK3C2G →	+0.017	+4.152	<.001	.009	3	1
BLOOD_Leukemia	ANKRD30BL →	+0.994	+4.874	<.001	.002	3	1
BLOOD_Leukemia	OR5P3 →	+0.104	+5.786	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

OR2D3 by IP6K3 expression — LARGE_INTESTINE

Explore this box plot interactively →