IP6K3

Across TCGA cell cohorts, IP6K3 mutation is significantly associated with the mutation status of many other genes, with 2,362 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IP6K3-associated genes across cancer lineages are FAM222B, CEP72, and PIK3CG. Each is linked with IP6K3 in more than 3 cancer types. Because this analysis shows association rather than direction, both IP6K3-to-partner and partner-to-IP6K3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM222B grouped by IP6K3-low versus IP6K3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IP6K3→partner) and Y-score (partner→IP6K3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FAM222B →	+5.277	+4.459	.005	.005	1	4
BLOOD_Leukemia	CEP72 →	+5.560	+4.736	.003	.003	1	4
BLOOD_Leukemia	PIK3CG →	+2.823	+3.665	.008	.008	1	4
OVARY	RUBCNL →	+4.217	+4.217	.001	.001	1	4
OVARY	ARID5B →	+3.217	+3.684	.006	.006	1	3
OVARY	EPS8 →	+5.217	+4.562	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,362 associations by consensus.

FAM222B by IP6K3 expression — CNS

Explore this box plot interactively →