IP6K2

Across TCGA patient cohorts, IP6K2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IP6K2-associated genes across cancer lineages are c-Met_pY1235, S6, and FASN. Each is linked with IP6K2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IP6K2-to-partner and partner-to-IP6K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by IP6K2-low versus IP6K2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IP6K2→partner) and Y-score (partner→IP6K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.072	+2.000	.031	.032	3	2
SKCM	S6 →	+0.533	+3.169	.016	.018	3	1
UCEC	FASN →	+0.435	+2.459	.014	.019	3	1
SKCM	Fibronectin →	+0.545	+2.321	.014	.035	2	1
UCEC	Notch1 →	+0.205	+3.179	.001	.010	2	1
SKCM	p27 →	-0.231	-2.321	.010	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

c-Met_pY1235 by IP6K2 expression — UCEC

Explore this box plot interactively →