IP6K2

Across TCGA pan-cancer cohorts, IP6K2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of IP6K2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where IP6K2 RNA is repressed in tumor relative to normal tissue. In most cancer types IP6K2 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, LIHC, and STAD are the cancer types where IP6K2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IP6K2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.222	<.001	10	view →
LIHC	Female	II,III,IV	+1.384	<.001	9	view →
STAD	Male	II,III,IV	+0.731	<.001	8	view →
BLCA	All	All	+0.682	.006	7	view →
KIRC	Male	II,III,IV	−0.337	<.001	6	view →
COAD	All	All	+0.298	<.001	6	view →
CHOL	Male	All	+1.920	<.001	5	view →
UCEC	All	III,IV	+0.521	.013	4	view →
BRCA	Female	All	−0.242	.002	4	view →
PRAD	All	All	+0.247	.009	2	view →
THCA	Male	IV	−0.533	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

IP6K2–KICH

Open the KICH breakdown →