INVS

Across TCGA patient cohorts, INVS protein abundance is significantly associated with the RNA expression of many other genes, with 4,802 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible INVS-associated genes across cancer lineages are IGKV1D-16, RUNDC3A-AS1, and KATNIP. Each is linked with INVS in more than 1 cancer types. Because this analysis shows association rather than direction, both INVS-to-partner and partner-to-INVS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, INVS versus IGKV1D-16 in PDAC, with a Pearson correlation of -0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INVS→partner) and Y-score (partner→INVS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	IGKV1D-16 →	-2.204	-0.583	<.001	.004	3	2
LUAD	RUNDC3A-AS1 →	-0.628	-0.342	<.001	.002	3	2
CCRCC	KATNIP →	-0.380	-0.342	<.001	.003	3	2
CCRCC	AMDHD1 →	+0.792	+0.305	.003	.006	3	2
BRCA	KCNN4 →	-1.868	-0.828	<.001	.007	3	1
BRCA	NANOG →	+0.110	+0.644	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,802 associations by consensus.

INVS vs IGKV1D-16 — PDAC

Explore this scatter interactively →