INVS

Across TCGA patient cohorts, INVS mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INVS-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and JNK_pT183_Y185. Each is linked with INVS in more than 2 cancer types. Because this analysis shows association rather than direction, both INVS-to-partner and partner-to-INVS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by INVS-low versus INVS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INVS→partner) and Y-score (partner→INVS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.346	+1.222	.003	.035	3	3
COAD	Caspase-7-cleavedD198 →	+1.292	+3.178	<.001	.010	3	3
UCEC	JNK_pT183_Y185 →	-0.203	-2.584	<.001	<.001	3	2
UCEC	JNK2 →	+0.182	+1.459	.004	.012	3	2
UCEC	TFRC →	+0.403	+1.222	.019	.035	3	2
UCEC	Chk2_pT68 →	-0.147	-2.674	.014	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ASNS by INVS expression — UCEC

Explore this box plot interactively →