INTU

Across TCGA patient cohorts, INTU mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTU-associated genes across cancer lineages are p38-MAPK_pT180_Y182, TFRC, and ATM. Each is linked with INTU in more than 2 cancer types. Because this analysis shows association rather than direction, both INTU-to-partner and partner-to-INTU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by INTU-low versus INTU-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTU→partner) and Y-score (partner→INTU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.461	-2.502	.001	.001	3	3
UCEC	TFRC →	+0.437	+2.459	.012	.018	3	3
UCEC	ATM →	-0.491	-2.794	.001	.002	3	3
LUAD	FOXO3a_pS318_S321 →	-0.149	-3.000	.010	.036	3	2
LUAD	p70-S6K →	+0.241	+3.000	.039	.036	3	2
UCEC	JNK2 →	+0.183	+2.026	.005	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

p38-MAPK_pT180_Y182 by INTU expression — UCEC

Explore this box plot interactively →