INTU

Across TCGA cell cohorts, INTU mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible INTU-associated genes across cancer lineages are CFHR2, MTRNR2L6, and HRG. Each is linked with INTU in more than 1 cancer types. Because this analysis shows association rather than direction, both INTU-to-partner and partner-to-INTU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by INTU-low versus INTU-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTU→partner) and Y-score (partner→INTU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CFHR2 →	+0.245	+5.124	<.001	<.001	3	2
BLOOD_Leukemia	MTRNR2L6 →	+0.074	+4.269	<.001	.002	3	2
BLOOD_Leukemia	HRG →	+0.406	+3.855	<.001	.007	3	1
BLOOD_Leukemia	KAAG1 →	+0.093	+3.855	<.001	.007	3	1
BLOOD_Leukemia	ASZ1 →	+0.120	+4.567	<.001	.001	3	1
BLOOD_Leukemia	DCLK3 →	+0.203	+3.769	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

CFHR2 by INTU expression — BLOOD_Leukemia

Explore this box plot interactively →