INTS8

Across TCGA pan-cancer cohorts, INTS8 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated INTS8 data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher INTS8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated INTS8 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where INTS8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.888	1.000	.003	31	view →
PDAC	DFS	Median	All	0.558	0.879	.001	30	view →
LUAD	OS	Median	III,IV	1.000	0.770	.006	20	view →
HNSC	DFS	Quartile	IV	0.462	0.949	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

INTS8–CCRCC (OS)

Open the CCRCC breakdown →