INTS8

Across TCGA pan-cancer cohorts, INTS8 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of INTS8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where INTS8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types INTS8 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, KIRC, and LUAD are the cancer types where INTS8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in INTS8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.214	<.001	12	view →
KIRC	Male	IV	+0.919	<.001	12	view →
LUAD	Male	III,IV	+1.226	<.001	11	view →
LIHC	Male	II,III,IV	+1.454	<.001	9	view →
BLCA	Male	All	+1.020	<.001	9	view →
COAD	Male	III,IV	+0.847	<.001	9	view →
KIRP	Male	III,IV	+0.793	<.001	9	view →
STAD	Male	II,III,IV	+1.295	<.001	8	view →
LUSC	Female	All	+1.140	<.001	8	view →
THCA	All	All	−0.311	<.001	8	view →
BRCA	All	II,III,IV	+0.855	<.001	6	view →
UCEC	All	All	+0.572	.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

INTS8–HNSC

Open the HNSC breakdown →