INTS8

Across TCGA patient cohorts, INTS8 mutation is significantly associated with the RNA expression of many other genes, with 1,754 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTS8-associated genes across cancer lineages are RNA5SP394, HMX3, and BAG1. Each is linked with INTS8 in more than 2 cancer types. Because this analysis shows association rather than direction, both INTS8-to-partner and partner-to-INTS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP394 grouped by INTS8-low versus INTS8-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS8→partner) and Y-score (partner→INTS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP394 →	+0.353	+4.760	<.001	<.001	3	3
UCEC	HMX3 →	+0.352	+1.367	.008	.006	3	3
UCEC	BAG1 →	+0.408	+1.776	<.001	.007	3	3
BRCA	TRGV11 →	+0.101	+3.685	<.001	.006	3	2
CESC	TRDJ4 →	+0.759	+3.612	<.001	.006	3	2
CESC	CPLX3 →	+0.010	+4.342	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,754 associations by consensus.

RNA5SP394 by INTS8 expression — CESC

Explore this box plot interactively →