INTS8

Across TCGA patient cohorts, INTS8 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTS8-associated genes across cancer lineages are ATM, 14-3-3_beta, and MEK1. Each is linked with INTS8 in more than 3 cancer types. Because this analysis shows association rather than direction, both INTS8-to-partner and partner-to-INTS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by INTS8-low versus INTS8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS8→partner) and Y-score (partner→INTS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.514	-2.401	<.001	.002	3	4
UCEC	14-3-3_beta →	-0.094	-2.295	.003	.005	3	2
UCEC	MEK1 →	+0.454	+3.906	<.001	<.001	3	2
UCEC	MSH2 →	-0.324	-2.558	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.259	+2.700	.002	.005	3	2
COAD	TSC1 →	-0.480	-3.000	<.001	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ATM by INTS8 expression — UCEC

Explore this box plot interactively →