INTS8

Across TCGA cell cohorts, INTS8 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible INTS8-associated genes across cancer lineages are SMCP, SLC32A1, and RAI2. Each is linked with INTS8 in more than 1 cancer types. Because this analysis shows association rather than direction, both INTS8-to-partner and partner-to-INTS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMCP grouped by INTS8-low versus INTS8-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS8→partner) and Y-score (partner→INTS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SMCP →	+0.068	+5.169	<.001	.005	3	2
BLOOD_Leukemia	SLC32A1 →	+0.655	+3.901	<.001	.006	3	1
BLOOD_Leukemia	RAI2 →	+0.111	+4.428	<.001	.001	3	1
BLOOD_Leukemia	BRDT →	+0.178	+4.342	<.001	.002	3	1
BLOOD_Leukemia	UNC45B →	+0.140	+4.408	.001	.001	3	1
BLOOD_Leukemia	SLC35G3 →	+0.034	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

SMCP by INTS8 expression — BREAST

Explore this box plot interactively →