INTS8

Across TCGA cell cohorts, INTS8 mutation is significantly associated with the mutation status of many other genes, with 2,873 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible INTS8-associated genes across cancer lineages are ZMIZ1, PRRC2B, and ARHGAP29. Each is linked with INTS8 in more than 3 cancer types. Because this analysis shows association rather than direction, both INTS8-to-partner and partner-to-INTS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZMIZ1 grouped by INTS8-low versus INTS8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS8→partner) and Y-score (partner→INTS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZMIZ1 →	+2.591	+3.263	.004	.004	1	4
BLOOD_Leukemia	PRRC2B →	+2.465	+3.686	.001	.001	1	4
STOMACH	ARHGAP29 →	+4.807	+4.807	.008	.008	1	4
BLOOD_Leukemia	MYH15 →	+2.465	+3.156	.005	.005	1	4
BLOOD_Leukemia	PTPRK →	+3.050	+3.624	.001	.001	1	4
STOMACH	DENND2B →	+4.807	+4.807	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,873 associations by consensus.

ZMIZ1 by INTS8 expression — BLOOD_Leukemia

Explore this box plot interactively →