INTS6

Across TCGA cell cohorts, INTS6 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INTS6-associated genes across cancer lineages are RSPH6A, IAPP, and KLHDC7B. Each is linked with INTS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both INTS6-to-partner and partner-to-INTS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RSPH6A grouped by INTS6-low versus INTS6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS6→partner) and Y-score (partner→INTS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RSPH6A →	+0.124	+3.688	<.001	.001	3	1
LARGE_INTESTINE	IAPP →	+0.412	+3.228	<.001	.003	3	1
LARGE_INTESTINE	KLHDC7B →	+0.682	+3.485	<.001	.004	3	1
LARGE_INTESTINE	OR2C1 →	+0.125	+4.047	<.001	.001	3	1
LARGE_INTESTINE	LONRF2 →	+0.505	+3.392	<.001	.006	3	1
LARGE_INTESTINE	NUPR2 →	+0.205	+2.688	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

RSPH6A by INTS6 expression — LARGE_INTESTINE

Explore this box plot interactively →