INTS4

Across TCGA patient cohorts, INTS4 protein abundance is significantly associated with the RNA expression of many other genes, with 14,007 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible INTS4-associated genes across cancer lineages are PTRH2, CHD6, and TLK2. Each is linked with INTS4 in more than 6 cancer types. Because this analysis shows association rather than direction, both INTS4-to-partner and partner-to-INTS4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, INTS4 versus PTRH2 in BRCA, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS4→partner) and Y-score (partner→INTS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PTRH2 →	+0.648	+0.179	<.001	<.001	3	7
HNSC	CHD6 →	+0.812	+0.182	<.001	.001	3	6
LUAD	TLK2 →	+0.357	+0.157	<.001	<.001	3	6
BRCA	HPGDS →	-0.744	-0.200	.001	<.001	2	7
HNSC	SKA3 →	+1.044	+0.236	<.001	<.001	3	6
BRCA	RPS17 →	+0.475	+0.128	.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,007 associations by consensus.

INTS4 vs PTRH2 — BRCA

Explore this scatter interactively →