INTS3

Across TCGA cell cohorts, INTS3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible INTS3-associated genes across cancer lineages are ARGFX, ETDC, and GZMK. Each is linked with INTS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both INTS3-to-partner and partner-to-INTS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARGFX grouped by INTS3-low versus INTS3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS3→partner) and Y-score (partner→INTS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARGFX →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	ETDC →	+0.507	+4.415	<.001	.007	3	1
BLOOD_Leukemia	GZMK →	+0.634	+4.037	<.001	.004	3	1
BLOOD_Leukemia	FGF3 →	+0.024	+4.060	<.001	.003	3	1
BLOOD_Leukemia	KHDC3L →	+0.211	+3.774	<.001	.008	3	1
BLOOD_Leukemia	MAGEL2 →	+0.348	+4.133	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ARGFX by INTS3 expression — LARGE_INTESTINE

Explore this box plot interactively →