INTS2

Across TCGA patient cohorts, INTS2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTS2-associated genes across cancer lineages are ERK2, Notch1, and Rad50. Each is linked with INTS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both INTS2-to-partner and partner-to-INTS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by INTS2-low versus INTS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS2→partner) and Y-score (partner→INTS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.132	+1.415	.037	.043	3	3
UCEC	Notch1 →	+0.166	+2.428	<.001	.001	3	2
UCEC	Rad50 →	-0.159	-1.392	.046	.019	3	2
UCEC	Raptor →	-0.102	-1.874	.042	.049	3	2
UCEC	STAT3_pY705 →	-0.303	-1.492	<.001	.027	3	2
UCEC	ATM →	-0.554	-2.087	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ERK2 by INTS2 expression — UCEC

Explore this box plot interactively →