INTS2

Across TCGA pan-cancer cohorts, INTS2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated INTS2 data layer compared with 10 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher INTS2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated INTS2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

KIRC, CESC, and LIHC are the cancer types where INTS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.798	0.459	<.001	68	view →
CESC	DFS	Quartile	All	0.746	0.901	.001	62	view →
LIHC	DFS	Quartile	All	0.409	0.635	<.001	55	view →
THCA	OS	Median	II,III,IV	0.845	0.979	.008	37	view →
KIRP	DFS	Tertile	IV	0.124	0.667	.010	37	view →
UCS	OS	Quartile	II,III,IV	0.657	0.233	.012	32	view →
READ	OS	Quartile	II,III,IV	0.861	0.306	.005	24	view →
UVM	DFS	Tertile	III,IV	0.246	0.780	.010	16	view →
HNSC	OS	Quartile	All	0.370	0.658	.003	15	view →
ESCA	OS	Median	II,III,IV	0.785	0.630	.025	12	view →
LGG	OS	Tertile	All	0.844	0.978	<.001	10	view →
SCLC	OS	Median	All	0.595	0.944	.016	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

INTS2–KIRC (DFS)

Open the KIRC breakdown →