INTS2

Across TCGA cell cohorts, INTS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,396 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible INTS2-associated GO terms across cancer lineages are DNA-templated DNA replication, Regulation of telomere capping, and Negative regulation of beige fat cell differentiation. Each is linked with INTS2 in more than 15 cancer types. Because this analysis shows association rather than direction, both INTS2-to-partner and partner-to-INTS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by INTS2-low versus INTS2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS2→partner) and Y-score (partner→INTS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DNA-templated DNA replication →	+0.103	+1.011	<.001	<.001	3	16
KIDNEY	Regulation of telomere capping →	+0.109	+0.612	<.001	.001	3	16
LUNG_NSCLC_LUSC	Negative regulation of beige fat cell differentiation →	+0.155	+1.011	.003	.002	3	15
LUNG_SCLC	Double-strand break repair →	+0.076	+1.064	<.001	<.001	3	15
PANCREAS	DNA recombination →	+0.079	+0.873	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.084	+1.027	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,396 associations by consensus.

DNA-templated DNA replication by INTS2 expression — LUNG_SCLC

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