INTS2

Across TCGA cell cohorts, INTS2 mutation is significantly associated with the RNA expression of many other genes, with 182 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INTS2-associated genes across cancer lineages are REG1B, SMIM33, and PNLIPRP3. Each is linked with INTS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both INTS2-to-partner and partner-to-INTS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by INTS2-low versus INTS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS2→partner) and Y-score (partner→INTS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	REG1B →	+2.150	+2.459	<.001	.002	3	2
LARGE_INTESTINE	SMIM33 →	+0.637	+2.577	<.001	.007	3	2
BLOOD_Leukemia	PNLIPRP3 →	+0.008	+3.551	.007	.009	3	2
SKIN	SPP2 →	+0.077	+3.347	<.001	.005	3	2
SOFT_TISSUE	RGSL1 →	+0.051	+4.169	<.001	.002	3	1
SOFT_TISSUE	PDHA2 →	+0.020	+4.392	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 182 associations by consensus.

REG1B by INTS2 expression — LARGE_INTESTINE

Explore this box plot interactively →