INTS1

Across TCGA patient cohorts, INTS1 mutation is significantly associated with the RNA expression of many other genes, with 4,226 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTS1-associated genes across cancer lineages are LINC02870, PUSL1, and MRRF. Each is linked with INTS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both INTS1-to-partner and partner-to-INTS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02870 grouped by INTS1-low versus INTS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS1→partner) and Y-score (partner→INTS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC02870 →	+0.495	+1.467	<.001	<.001	3	4
COAD	PUSL1 →	+0.421	+2.415	.006	.003	3	4
UCEC	MRRF →	+0.375	+2.200	<.001	<.001	3	4
UCEC	UHRF1 →	+0.576	+1.162	<.001	.002	3	3
CESC	CSPG5 →	+1.008	+3.469	<.001	.002	3	3
BRCA	SCNM1 →	+0.554	+3.348	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,226 associations by consensus.

LINC02870 by INTS1 expression — UCEC

Explore this box plot interactively →