INTS1

Across TCGA pan-cancer cohorts, INTS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated INTS1 data layer compared with 10 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher INTS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated INTS1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and THYM show a favorable association.

MESO, CESC, and BLCA are the cancer types where INTS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	All	0.254	0.467	.002	77	view →
CESC	DFS	Quartile	All	0.701	0.876	<.001	72	view →
BLCA	DFS	Tertile	All	0.252	0.424	.004	59	view →
ACC	DFS	Tertile	All	0.470	0.808	<.001	55	view →
LUAD	DFS	Quartile	All	0.677	0.845	<.001	43	view →
SCLC	OS	Quartile	All	0.816	0.493	.003	40	view →
LGG	DFS	Tertile	All	0.331	0.498	<.001	35	view →
LIHC	DFS	Quartile	All	0.266	0.475	<.001	33	view →
KICH	OS	Median	III,IV	0.194	0.863	.001	32	view →
THYM	OS	Tertile	II,III,IV	1.000	0.647	.004	30	view →
SKCM	DFS	Quartile	All	0.121	0.277	.003	25	view →
PAAD	OS	Median	All	0.487	0.214	.002	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

INTS1–MESO (DFS)

Open the MESO breakdown →