INTS1

Across TCGA cell cohorts, INTS1 mutation is significantly associated with the RNA expression of many other genes, with 965 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INTS1-associated genes across cancer lineages are POLI, DYM, and KCNJ11. Each is linked with INTS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both INTS1-to-partner and partner-to-INTS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLI grouped by INTS1-low versus INTS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS1→partner) and Y-score (partner→INTS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	POLI →	+0.632	+1.808	.001	.001	3	3
LARGE_INTESTINE	DYM →	+0.590	+2.246	.002	.001	3	3
LARGE_INTESTINE	KCNJ11 →	+0.570	+2.459	.004	.003	3	3
LARGE_INTESTINE	MTHFD2 →	+0.885	+1.808	<.001	.001	3	3
LUNG_NSCLC_LUAD	DOK2 →	+0.038	+3.945	.002	<.001	3	3
BONE	BTNL3 →	+0.006	+5.169	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 965 associations by consensus.

POLI by INTS1 expression — LARGE_INTESTINE

Explore this box plot interactively →