INSYN2A

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, INSYN2A mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INSYN2A-associated genes across cancer lineages are A-Raf_pS299, INPP4B, and MEK1. Each is linked with INSYN2A in more than 1 cancer types. Because this analysis shows association rather than direction, both INSYN2A-to-partner and partner-to-INSYN2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSYN2A→partner) and Y-score (partner→INSYN2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECA-Raf_pS299 →-0.094-1.906.015.01532
UCECINPP4B →-0.288-3.807.006<.00132
UCECMEK1 →+0.445+2.700<.001<.00132
UCECRab25 →-0.319-2.000.002.00932
UCECRad50 →-0.166-2.308.035.03332
UCECShc_pY317 →-0.142-1.765.004.01332
Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration