Across TCGA patient cohorts, INSYN1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INSYN1-associated genes across cancer lineages are Ku80, 4E-BP1, and 14-3-3_beta. Each is linked with INSYN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both INSYN1-to-partner and partner-to-INSYN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSYN1→partner) and Y-score (partner→INSYN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.302	+2.920	.002	.001	3	3
UCEC	4E-BP1 →	+0.339	+3.351	.003	.005	3	2
UCEC	14-3-3_beta →	-0.102	-3.295	.017	.009	3	1
UCEC	EGFR_pY1068 →	-0.242	-2.321	.022	.034	3	1
UCEC	ERK2 →	+0.220	+1.700	.007	.044	3	1
UCEC	JNK2 →	+0.333	+1.901	<.001	.028	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

INSYN1 survival (RNA) · tumor vs normal (RNA) · all INSYN1 data types