Across TCGA cell cohorts, INSYN1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible INSYN1-associated genes across cancer lineages are PF4V1, TTLL8, and REG1B. Each is linked with INSYN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both INSYN1-to-partner and partner-to-INSYN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSYN1→partner) and Y-score (partner→INSYN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PF4V1 →	+0.265	+4.115	<.001	.001	3	1
LARGE_INTESTINE	TTLL8 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	REG1B →	+2.638	+3.196	<.001	.007	3	1
LARGE_INTESTINE	ELOA3DP →	+0.027	+3.688	<.001	.002	3	1
LARGE_INTESTINE	H4C13 →	+0.313	+3.592	.002	.006	3	1
LARGE_INTESTINE	OR6Q1 →	+0.015	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

INSYN1 survival (RNA) · tumor vs normal (RNA) · all INSYN1 data types